Researchers at the University of Technology Sydney have developed a series of ivermectin-resistant strains of the model nematode Caenorhabditis elegans through step-wise exposure to increasing doses of ivermectin. Resistant strains display a multidrug resistance phenotype with cross-resistance to the related drug moxidectin and to other anthelmintics, levamisole and pyrantel, but not albendazole. This innovation is of significant value to anthelmintic drug discovery, especially for screening new generation candidates that overcome resistance to existing drugs.

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