In human innate immunity, an inflammatory response resulting in pathogen clearance is characterised by recruitment and activation of immune cells to sites of infection or injury. Recruitment of inflammatory cells can lead to overt tissue damage and inflammation, leading to disease pathology. The complement system plays an important role in mediating this response.

Researchers at The University of Queensland have identified a novel target for modulating inflammation: the receptor of complement component C3a (C3aR).  Using established mouse models of inflammation the research has shown that activation of C3aR, through the use of C3aR agonists, significantly reduces the inflammatory response.  Potential therapeutics based on selective activation of C3aR may provide an alternative to current anti-inflammatory therapies.

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