Many traditional 2D culture models have failed to recapitulate the complex biology and pathophysiology of human disease which contributes towards drug candidate failures at the costly clinical phases of development. Human organoid cultures of many different tissues (e.g. liver, kidney, brain, intestines, heart) have achieved more accurate models of human organs in vitro but are often costly and limited to low throughput.
Researchers at The University of Queensland have developed novel 96-well platform for the fabrication, culture and analysis of human cardiac organoids, termed the Heart-Dyno.
Status & Access
Maturation media optimised and device prototypes used extensively in proof of principle studies.
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 Horvath et al., Nature Reviews Drug Discovery, 2016